Actilyse (Alteplase) is a high-potency, life-saving "clot-buster" medication used in emergency medicine to dissolve blood clots that cause life-threatening cardiovascular events. As a recombinant tissue plasminogen activator (rt-PA), it works by converting plasminogen to plasmin, which then breaks down the fibrin mesh of a clot. The Treatment Set is a specialized emergency pack containing the dry substance, sterile solvent, and a transfer cannula for rapid, precise reconstitution in a hospital setting.
Product Type: Thrombolytic (Fibrinolytic) Agent
Active Ingredient: Alteplase (50mg)
Manufacturer: Boehringer Ingelheim
Set Contents: 1 Vial of Powder (50mg), 1 Vial of Solvent (50ml Water for Injection), and 1 Transfer Cannula
Route: Intravenous (IV) Injection/Infusion
Availability: Strictly Hospital Use Only — Emergency Specialist administration
Suitable For: Critical care patients with acute ischemic stroke, heart attack, or massive lung clots
Actilyse is a time-critical medication used for "reperfusion therapy"—restoring blood flow to vital organs. It is indicated for:
Acute Ischemic Stroke: Dissolving clots in the brain to prevent permanent disability. Crucial: Must be administered within 4.5 hours of symptom onset.
Acute Myocardial Infarction (Heart Attack): Reopening blocked coronary arteries to save heart muscle. Most effective if given within 6 to 12 hours.
Acute Massive Pulmonary Embolism (PE): Dissolving large clots in the lungs that are causing unstable blood pressure and heart strain.
Occluded Catheters: Occasionally used in lower doses to clear blocked central venous access devices.
High Bleeding Risk: Actilyse cannot be used in patients with a high risk of hemorrhage. This includes:
Current or recent internal bleeding or a history of brain hemorrhage.
Recent major surgery, biopsy, or serious trauma within the last 3 months.
Severe Uncontrolled Hypertension (Blood Pressure over 185/110 mmHg).
Patients on effective "blood thinners" (like Warfarin with a high INR).
Suspected Aortic Dissection or acute pancreatitis.
Stroke Mimics: Before treating a stroke, a CT scan must be performed to rule out a "hemorrhagic" (bleeding) stroke, as Actilyse would be fatal in such cases.
Actilyse is administered as a weight-based dose. The 50mg set is reconstituted to a concentration of 1mg/ml.
General Protocol Examples:
For Ischemic Stroke: Total dose of 0.9 mg/kg (max 90mg). 10% is given as an initial IV bolus over 1 minute, followed by the remaining 90% as a continuous infusion over 60 minutes.
For Heart Attack (90-min regimen): 15mg bolus, followed by 50mg over 30 mins, then 35mg over 60 mins (for patients over 65kg).
Preparation Tip:
Using the included Transfer Cannula, the sterile water is transferred into the Actilyse vial. The vial should be swirled gently—never shaken—to avoid excessive foaming, which can degrade the protein.
The most significant risk is major bleeding, including intracranial (brain) or gastrointestinal bleeding. Patients must be monitored in an ICU or specialized Stroke Unit for 24 hours. Other effects include low blood pressure (hypotension), fever, and occasional allergic reactions (angioedema), particularly in patients also taking ACE inhibitors for blood pressure.
Store the unopened treatment set in a cool, dry place below 25°C to 30°C and protect it from light. Once reconstituted, the solution should ideally be used immediately, though it is chemically stable for up to 24 hours if stored in a refrigerator (2°C to 8°C).
Q: Can I buy this for my "First Aid Box" at home?
A: No. Actilyse is a complex, high-risk medication that requires a neurologist or cardiologist to administer. It is only stocked in emergency rooms and ICUs.
Q: Why is "Time" so important?
A: In a stroke, "Time is Brain." Every minute a clot blocks blood flow, millions of brain cells die. The benefit of Actilyse decreases rapidly the longer you wait.
Q: Will it clear a "clot" in my leg (DVT)?
A: While it can dissolve clots anywhere, it is usually reserved for life-threatening clots in the brain, heart, or lungs. Leg clots are typically treated with heparin or oral anticoagulants.
The Actilyse Treatment Set is a high-value, specialty emergency item. In Nigeria, it is available through specialized pharmaceutical distributors or hospital procurement centers like Sanlive Pharmacy. Due to the critical nature of the drug, we ensure 100% authenticity and proper storage history.
Guaranteed authentic Boehringer Ingelheim stock.
Verified storage history to ensure enzyme stability.
Priority handling for hospital emergency orders.
Licensed pharmacists available for clinical protocol verification.
For hospital emergency orders or specialized medical procurement, contact Sanlive Pharmacy today.
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